Many receptors for neurotransmitters and hormones rely upon members of the Gqα family of
heterotrimeric G proteins to exert their actions on target cells. Gα subunits of the Gq class of …

Muscarinic acetylcholine receptors, which comprise five subtypes (M1-M5 receptors), are
expressed in both the CNS and PNS (particularly the target organs of parasympathetic …

Murine G alpha 14 and G alpha 15 cDNAs encode distinct alpha subunits of heterotrimeric
guanine nucleotide-binding proteins (G proteins). These alpha subunits are related to …

High efficiency transient transfection was used to introduce cDNA corresponding to various
G protein alpha subunits into Cos-7 cells. The proteins that were subsequently synthesized …

The relative specificities of members of the G alpha q family of GTP-binding proteins were
tested for their ability to activate different phosphoinositide-specific phospholipase C (PI …

The first 15 years, or so, brought the realization that there existed a G protein coupled signal
transduction mechanism by which hormone receptors regulate adenylyl cyclases and the …

I. Introduction T HE ROLE of heterotrimeric guanine nucleotide binding proteins (G proteins)
in signal transduction was first covered in Endocrine Reviews in 1981, when three distinct G …

In order to determine which portion of phosphoinositide-specific phospholipase C (PLC)-
beta 1 is required for activation by G alpha q, a series of specific deletions and truncations of …

Bovine liver cytosol contains a phosphoinositide phospholipase C (PLCcyt) that is activated
by guanosine 5'-O-(3-thio) triphosphate (GTP gamma S)-activated G-proteins from liver …

Metabotropic glutamate receptors consist of at least six different subtypes termed mGluR1-
mGluR6. They belong to the family of G protein-coupled receptors and commonly possess …