Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of
years, it has helped humans fight diseases and protect life, health, and reproduction …

Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

The role of two-pore channel 2 (TPC2), one of the few cation channels localized on
endolysosomal membranes, in cancer remains poorly understood. Here, we report that …

Background In this study, the network pharmacological methods were used to predict the
target of effective components of compounds in Zisheng Shenqi Decoction (ZSD, or …

Hyperuricemia characterized by high serum levels of uric acid (UA,> 6.8 mg/dL) is regarded
as a common chronic metabolic disease. When used as a food supplement, naringenin …

Abstract Evodiae fructus (Wu‑Zhu‑Yu in Chinese) can be isolated from the dried, unripe fruits
of Tetradium ruticarpum and is a well‑known traditional Chinese medicine that is applied …

Saikosaponin a (Ssa) is an active ingredient of the Chinese herbal plant Radix Bupleuri
(RB) and has severe hepatotoxicity. However, biomolecular mechanisms involved in Ssa …

The gut microbiota is emerging as a prominent player in maintaining health through several
metabolic and immune pathways. Dysregulation of gut microbiota composition, also known …

The identification of anticancer active ingredients and their molecular targets in traditional
Chinese medicine is a great challenge in modern pharmacology research. Evodiamine is …

Simple Summary Cancer is a major global health concern, with the Mitogen-activated
protein kinase (MAPK) pathway playing a crucial role in cancerous diseases. Indole …