Cells display a large variety of shapes when plated in classical culture conditions despite
their belonging to a common cell type. These shapes are transitory, since cells permanently …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Focal adhesion kinase (FAK) is a member of a family of non-receptor protein-tyrosine
kinases that regulates integrin and growth factor signaling pathways involved in cell …

Cellular forces generated by the actomyosin cytoskeleton and transmitted to the extracellular
matrix (ECM) through discrete, integrin-based protein assemblies, that is, focal adhesions …

Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase localized at focal
adhesions and is believed to mediate adhesion-stimulated effects. Although ablation of FAK …

The motility and morphogenesis of endothelial cells is controlled by spatio-temporally
regulated activation of integrin adhesion receptors, and integrin activation is stimulated by …

The ability of cells to form tissues represents one of the most fundamental issues in biology.
However, it is unclear what triggers cells to adhere to one another in tissues and to migrate …

Cells can sense and transduce a broad range of mechanical forces into distinct sets of
biochemical signals that ultimately regulate cellular processes, including adhesion …

The myofibroblast has been shown to have a key role in tissue reconstruction after injury
and pathological changes characterized by fibrosis. Force generation by the myofibroblast …

Cell adhesion to extracellular matrix is mediated by receptor-ligand interactions. When a cell
first contacts a surface, it spreads, exerting traction forces against the surface and forming …