Mechanical interactions between a cell and its environment regulate migration, contractility,
gene expression, and cell fate. We integrated micropatterned substrates to engineer …

Cancer cells arise from normal cells through the acquisition of a series of mutations in
oncogenes and tumour suppressor genes. Mouse models of human cancer often rely on …

The c-Jun amino-terminal kinase (JNK) is generally thought to be involved in inflammation,
proliferation and apoptosis,. Accordingly, its substrates are transcription factors and anti …

Focal contacts, focal complexes and related extracellular matrix adhesions are used by cells
to explore their environment. These sites act as mechanosensory 'devices', where internal …

Cell adhesion, spreading and migration require the dynamic formation and dispersal of
contacts with the extracellular matrix (ECM). In vivo, the number, availability and distribution …

The physical properties of the cellular environment are involved in regulating the formation
and maintenance of tissues. In particular, substrate rigidity appears to be a key factor …

Cell adhesions link cells to the extracellular matrix (ECM) and to each other and depend on
interactions with the actin cytoskeleton. Both cell–ECM and cell–cell adhesion sites contain …

Cell migration directed by spatial cues, or taxis, is a primary mechanism for orchestrating
concerted and collective cell movements during development, wound repair, and immune …

Forces exerted by stationary cells have been investigated on the level of single focal
adhesions by combining elastic substrates, fluorescence labeling of focal adhesions, and …

Integrins are cell–substrate adhesion molecules that provide the essential link between the
actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3 …