Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As
the major force-bearing adhesion-receptor protein, integrins have a central role in how cells …

The function of the integrin family of receptors as central mediators of cell-extracellular
matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and …

Mechanical cues can influence the manner in which cells generate traction forces and form
focal adhesions. The stiffness of a cell's substrate and the available area on which it can …

Surface probe measurements of the elasticity of thin film matrices as well as biological
samples prove generally important to understanding cell attachment across such systems …

We present a reconstruction algorithm that resolves cellular tractions in diffraction-limited
nascent adhesions (NAs). The enabling method is the introduction of sparsity regularization …

To identify cytoskeletal proteins that change conformation or assembly within stressed cells,
in situ labeling of sterically shielded cysteines with fluorophores was analyzed by …

Dynamic actin network at the leading edge of the cell is linked to the extracellular matrix
through focal adhesions (FAs), and at the same time it undergoes retrograde flow with …

Integrins have emerged as key sensory molecules that translate chemical and physical cues
from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior …

Twenty years ago, we proposed a model of developmental control based on tensegrity
architecture, in which tissue pattern formation in the embryo is controlled through …

Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors
catalyze the conversion of chemical energy into directed movement and force thereby acting …