1 Peripheral inflammation is associated with the local production of neuroactive
inflammatory cytokines and growth factors. These may contribute to inflammatory pain and …

Neurotrophic factors comprise a broad family of biomolecules–most of which are peptides or
small proteins–that support the growth, survival and differentiation of both developing and …

Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

The aim of this investigation was to determine whether murine models of inflammatory,
neuropathic and cancer pain are each characterized by a unique set of neurochemical …

Mechanisms underlying the hyperalgesia induced by a single systemic injection of nerve
growth factor (NGF) in adult rats were studied in vivo. A single dose of NGF initiated a …

The nature of dorsal root reflexes (DRRs) and their possible role in peripheral inflammation
and the consequent hyperalgesia are reviewed. The history of DRRs and the relationship of …

Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of
as a passive organ not involved in the development of abnormal aberrent neuropathic pain …

Cutaneous wound healing is a complex process that aims to re-establish the original
structure of the skin and its functions. Among other disorders, peripheral neuropathies are …

Dry eye syndrome (DES) refers to a spectrum of ocular surface diseases with diverse and
frequently multiple aetiologies. The common feature of the various manifestations of DES is …

Recent findings have shed new light on the role of peripheral nerves in the skin and
established a modern concept of cutaneous neurobiology. Closely related monodirectional …