The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …

Background Proper sedation for neonates undergoing uncomfortable procedures may
reduce stress and avoid complications. Midazolam is a short‐acting benzodiazepine that is …

Endotracheal intubation is a common procedure in newborn care. The purpose of this
clinical report is to review currently available evidence on use of premedication for …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Midazolam is a parenteral benzodiazepine with sedative, amnesic, anxiolytic, muscle
relaxant and anticonvulsant properties. The drug exerts its clinical effect by binding to a …

Monitoring the safety of medicine use in children is of paramount importance since during
the clinical development of medicines only limited data on this aspect are generated through …

Historically, pain in the preterm infant has been poorly understood and often unrecognized.
1 There have been major advances in understanding the developmental physiology of …

BACKGROUND:: Preterm and full-term neonates admitted to the neonatal intensive care unit
or elsewhere in the hospital are routinely subjected to invasive procedures that can cause …

This statement is intended for health care professionals caring for neonates (preterm to 1
month of age). The objectives of this statement are to: 1. Increase awareness that neonates …

To assess the incidence of postneonatal epilepsy in term infants treated with antiepileptic
drugs for neonatal seizure discharges that were detected with amplitude-integrated …