The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

The isolated perfused mammalian heart preparation was established in 1897 by Oscar
Langendorff. The method was developed on the basis of the isolated perfused frog heart …

Safety Pharmacology is a rapidly developing discipline that uses the basic principles of
pharmacology in a regulatory‐driven process to generate data to inform risk/benefit …

In the United States, sudden cardiac death accounts for an estimated 300,000 to 350,000
cases each year, with 80,000 presenting as the first manifestation of a preexisting …

Sudden cardiac death forms a major cause of mortality. Myocardial ischemia-induced
ventricular fibrillation (VF) is frequently the underlying mechanism. Ventricular arrhythmias …

Aims Acute ischemia is a major cause of sudden arrhythmic death, further promoted by
potassium current blockers. Macro-reentry around the ischemic region and early …

Ventricular fibrillation (VF) and myocardial ischemia are inseparable. The first clinical
manifestation of myocardial ischemia or infarction may be sudden cardiac death in 20–25 …

Bisphenol A (BPA) is an environmental estrogenic endocrine disruptor that may have
adverse health impacts on a range of tissue/systems. In previous studies, we reported that …

Objectives: The goal of this study was to establish the role of ventricular filling on the 1b
phase of ischemia-induced arrhythmias. Background: Ischemia-induced ventricular …

Murine myocardium contains diminutive amounts of calcium-independent phospholipase A
2 (iPLA 2) activity (< 5% that of human heart), and malignant ventricular tachyarrhythmias …