Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

F Demontis, R Piccirillo, AL Goldberg… - Disease models & …, 2013 - journals.biologists.com
A characteristic feature of aged humans and other mammals is the debilitating, progressive
loss of skeletal muscle function and mass that is known as sarcopenia. Age-related muscle …

A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome

NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Caloric restriction improves health and survival of rhesus monkeys

JA Mattison, RJ Colman, TM Beasley, DB Allison… - Nature …, 2017 - nature.com
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been …

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

RJ Colman, TM Beasley, JW Kemnitz… - Nature …, 2014 - nature.com
Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-
associated disorders in short-lived species, from unicellular organisms to laboratory mice …

Caloric restriction delays disease onset and mortality in rhesus monkeys

RJ Colman, RM Anderson, SC Johnson, EK Kastman… - Science, 2009 - science.org
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse
species; however, its effect on resistance to illness and mortality in primates has not been …

[图书][B] Histopathology of preclinical toxicity studies: interpretation and relevance in drug safety evaluation

P Greaves - 2011 - books.google.com
Chapter 1: Introduction--Chapter 2: Integumentary System----Skin and subcutaneous tissue--
Chapter 3: Mammary Gland--Chapter 4: Haemopoietic and Lymphatic Systems …

Longevity: lesson from model organisms

G Taormina, F Ferrante, S Vieni, N Grassi, A Russo… - Genes, 2019 - mdpi.com
Research on longevity and healthy aging promises to increase our lifespan and decrease
the burden of degenerative diseases with important social and economic effects. Many …

[HTML][HTML] Non-human primates as a model for aging

RJ Colman - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

Rhesus macaques as a tractable physiological model of human ageing

KL Chiou, MJ Montague… - … of the Royal …, 2020 - royalsocietypublishing.org
Research in the basic biology of ageing is increasingly identifying mechanisms and
modifiers of ageing in short-lived organisms such as worms and mice. The ultimate goal of …

[HTML][HTML] International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): non-proliferative and proliferative lesions of the non-human primate (M …

K Colman, RN Andrews, H Atkins… - Journal of toxicologic …, 2021 - ncbi.nlm.nih.gov
Abstract The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions Project (www. toxpath. org/inhand. asp) is a joint initiative of the Societies of …