Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Simple Summary New treatments that utilize targeted therapeutic agents or invigorations of
the host immune system to destroy cancer cells are not effective against all cancers or …

The 3D genome organization and its dynamic modulate genome function, playing a pivotal
role in cell differentiation and development. CTCF and cohesin, acting as the core …

Species within nearly all extant animal lineages are capable of regenerating body parts.
However, it remains unclear whether the gene expression programme controlling …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐
Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory …

YY1 affects tumorigenesis and metastasis in multiple ways. However, the function of YY1
and the potential mechanisms through which it operates in gastric cancer (GC) progression …

The three-dimensional genome structure organized by CTCF is required for development.
Clinically identified mutations in CTCF have been linked to adverse developmental …

Tumor metastasis is a leading cause of death in nasopharyngeal carcinoma (NPC) patients.
Previous research has identified that transcription factor Yin Yang 1 (YY1) acts as a tumor …

Endogenous retroviruses (ERVs) are important components of transposable elements that
constitute∼ 40% of the mouse genome. ERVs exhibit dynamic expression patterns during …