Populations in many nations today are rapidly ageing. This unprecedented demographic
change represents one of the main challenges of our time. A defining property of the ageing …

Apoptosis can be evoked by reactive oxygen species (ROS)-induced mitochondrial release
of the proapoptotic factors cytochrome c and apoptosis-inducing factor (AIF). Because …

Prepubertal rats display heightened hormonal stress reactivity compared with adults in that
levels of ACTH and corticosterone take twice as long (ie 40–60 min) to return to baseline …

In mammals the two proteins UCP2 and UCP3 are highly similar to the mitochondrial
uncoupling protein found in the brown adipose tissue (UCP1). Accordingly, it was proposed …

An accurate method for the quantification of carboxymethyllysine (CML) in food samples is
evaluated. CML, a stable advanced Maillard compound, is considered as an useful marker …

A high dietary fat intake and low physical activity characterize the current Western lifestyle.
Dietary fatty acids do not stimulate their own oxidation and a surplus of fat is stored in white …

Plant mitochondrial uncoupling protein (UCP) is activated by superoxide suggesting that it
may function to minimize mitochondrial reactive oxygen species (ROS) formation. However …

Mitochondria are fascinating organelles involved in various cellular-metabolic activities that
are integral for mammalian development. Although they perform diverse, yet interconnected …

Mitochondria are the major cellular producers of reactive oxygen species (ROS), and
mitochondrial ROS production increases steeply with increased proton-motive force. The …

Myocardial ischemia-reperfusion (IR) injury may result in cardiomyocyte dysfunction.
Mitochondria play a critical role in cardiomyocyte recovery after IR injury. The mitochondrial …