Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …

The pure recombinant and synthetic antigens used in modern day vaccines are generally
less immunogenic than older style live/attenuated and killed whole organism vaccines. One …

Innate immunity is a highly effective set of conserved mechanisms used by multicellular
organisms to recognize and counter the constant threat of microbial infections. There is …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …

Vaccine efficacy is optimized by addition of immune adjuvants. However, although adjuvants
have been used for over a century, to date, only few adjuvants are approved for human use …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …

Alzheimer's disease is the most common cause of dementia and the only illness among the
top 10 causes of death for which there is no disease-modifying therapy. The failure rate of …

The use of protein or DNA in vaccination process rather than living or attenuated
microorganism, aims at the increase of the vaccines safety. However, in these cases, the use …

Bacterial pneumonia is a leading cause of mortality in the United States. Innate immune
responses, including type-1 cytokine production, are critical to the effective clearance of …

Here we describe the design and construction of multivalent circular DNA aptamers. Four
aptameric binding motifs directed at blood-borne targets are used as a model set from which …