The blood–brain barrier in systemic infection and inflammation
I Galea - Cellular & molecular immunology, 2021 - nature.com
The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …
brain. Its primary function is to protect central neurons while signaling the presence of …
[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration
A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …
Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …
generation of seizures. The pathogenic processes of seizure generation and recurrence are …
Pathophysiology and treatment of cerebral edema in traumatic brain injury
RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
Aquaporin-4 water channel in the brain and its implication for health and disease
S Mader, L Brimberg - Cells, 2019 - mdpi.com
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …
Glia as sculptors of synaptic plasticity
L Sancho, M Contreras, NJ Allen - Neuroscience Research, 2021 - Elsevier
Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain
development and function. Three major classes of glia in the central nervous system (CNS) …
development and function. Three major classes of glia in the central nervous system (CNS) …
Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
[HTML][HTML] CNS pharmacology of NKCC1 inhibitors
W Loescher, K Kaila - Neuropharmacology, 2022 - Elsevier
Abstract The Na–K–2Cl cotransporter NKCC1 and the neuron-specific K–Cl cotransporter
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …
The glymphatic system: a novel therapeutic target for stroke treatment
T Lv, B Zhao, Q Hu, X Zhang - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The glymphatic system (GS) is a novel defined brain-wide perivascular transit network
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …
Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders
Y Takai, T Misu, H Suzuki, T Takahashi, H Okada… - Brain, 2021 - academic.oup.com
Abstract Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-
IgG+ NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by …
IgG+ NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by …