Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to
the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely …

Background First‐and third‐generation retinoids are the main treatment for acne. Even
though efficacious, they lack full selectivity for retinoic acid receptor (RAR) γ, expressed in …

Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including
inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid …

Abstract Inhibitor of differentiation‐1 (Id‐1) is a member of helix–loop–helix (HLH) family of
proteins that regulate gene transcription through their inhibitory binding to basic‐HLH …

Retinoic acid regulates the expression of genes involved in cell proliferation, differentiation,
and survival by direct control of gene transcription via activation of nuclear retinoid receptors …

Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) results in a variety of lesions in
mammals including severe skin lesions. The majority of TCDD's biological effects are …

Abstract Poly (ADP-ribose) polymerase (PARP) is a family of nuclear proteins which regulate
a number of cell functions, such as DNA repair, transcription, remodelling of chromatin …

Objective Id2 (inhibitor of DNA-binding 2), a member of the helix–loop–helix family of
transcription regulators, plays important roles in cell proliferation and differentiation. Recent …

The precise causes of psoriasis, a chronic skin disorder characterized by hyperproliferation
of keratinocytes and incomplete keratinization, are unclear. It is known that expression of …