The role of O-GlcNAcylation in RNA polymerase II transcription
BA Lewis - Journal of Biological Chemistry, 2024 - ASBMB
Abstract Eukaryotic RNA polymerase II (RNAPII) is responsible for the transcription of the
protein-coding genes in the cell. Enormous progress has been made in discovering the …
protein-coding genes in the cell. Enormous progress has been made in discovering the …
Nono induces Gadd45b to mediate DNA repair
V Mamontova, B Trifault, K Burger - Life Science Alliance, 2024 - life-science-alliance.org
RNA-binding proteins are frequently deregulated in cancer and emerge as effectors of the
DNA damage response (DDR). The non-POU domain–containing octamer-binding protein …
DNA damage response (DDR). The non-POU domain–containing octamer-binding protein …
Promoter and Gene-Body RNA-Polymerase II co-exist in partial demixed condensates
A Changiarath, D Flores-Solis, JJ Michels… - bioRxiv, 2024 - biorxiv.org
In cells, transcription is tightly regulated on multiple layers. The condensation of the
transcription machinery into distinct phases is hypothesised to spatio-temporally fine tune …
transcription machinery into distinct phases is hypothesised to spatio-temporally fine tune …
Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II
R Vidal, E Leen, S Herold, M Müller, D Fleischhauer… - bioRxiv, 2023 - biorxiv.org
MYC family oncoproteins regulate the expression of a large number of genes and broadly
stimulate elongation by RNA polymerase II. While the factors that control the chromatin …
stimulate elongation by RNA polymerase II. While the factors that control the chromatin …
TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing
TFIID is an essential basal transcription factor, crucial for RNA polymerase II (pol II) promoter
recognition and transcription initiation. The TFIID complex consists of the TATA-binding …
recognition and transcription initiation. The TFIID complex consists of the TATA-binding …
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
B Trifault, V Mamontova, G Cossa… - Nucleic Acids …, 2024 - academic.oup.com
RNA-binding proteins emerge as effectors of the DNA damage response (DDR). The
multifunctional non-POU domain-containing octamer-binding protein NONO/p54nrb marks …
multifunctional non-POU domain-containing octamer-binding protein NONO/p54nrb marks …