Cellular and molecular mechanisms of curcumin in prevention and treatment of disease
Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …
Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy
X Cai, J Wang, J Wang, Q Zhou, B Yang, Q He… - Pharmacological …, 2020 - Elsevier
Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …
Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent
Monocytes and macrophages are important cells of the innate immune system that have
diverse functions, including defense against invading pathogens, removal of dead cells by …
diverse functions, including defense against invading pathogens, removal of dead cells by …
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
Chemokines belong to the family of cytokines with chemoattractant properties that regulate
chemotaxis and leukocyte migration, as well as the induction of angiogenesis and …
chemotaxis and leukocyte migration, as well as the induction of angiogenesis and …
Molecular mechanisms of curcumin in the pathogenesis of metabolic dysfunction associated Steatotic liver disease
M Guariglia, F Saba, C Rosso, E Bugianesi - Nutrients, 2023 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial
condition characterized by insulin resistance, oxidative stress, chronic low-grade …
condition characterized by insulin resistance, oxidative stress, chronic low-grade …
Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes
S Guo, X Meng, X Yang, X Liu, C Ou-Yang… - Acta Pharmacologica …, 2018 - nature.com
Cardiac fibrosis is considered the initial change of diabetic cardiomyopathy (DCM). We have
shown that curcumin alleviates collagen deposition in DCM, but the mechanism remains …
shown that curcumin alleviates collagen deposition in DCM, but the mechanism remains …
Food components with antifibrotic activity and implications in prevention of liver disease
M Bae, YK Park, JY Lee - The Journal of Nutritional Biochemistry, 2018 - Elsevier
Increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in parallel with the obesity
epidemic has been a major public health concern. NAFLD is the most common chronic liver …
epidemic has been a major public health concern. NAFLD is the most common chronic liver …
A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids
X Pan, X Ma, Y Jiang, J Wen, L Yang… - Evidence‐based …, 2020 - Wiley Online Library
Liver fibrosis resulting from continuous long‐term hepatic damage represents a heavy
burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with …
burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with …
Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial
M Nouri‐Vaskeh, A Malek Mahdavi… - Phytotherapy …, 2020 - Wiley Online Library
Recent reports indicated that curcumin had beneficial effects in animal models of liver injury
and cirrhosis. Current study aimed to investigate the effects of curcumin supplementation in …
and cirrhosis. Current study aimed to investigate the effects of curcumin supplementation in …
[HTML][HTML] Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion
XA Zhao, G Chen, Y Liu, Y Chen, H Wu, Y Xiong… - Biomedicine & …, 2018 - Elsevier
Curcumin has been reported to have anti-fibrotic effect. However, the anti-fibrotic
mechanism of curcumin for liver fibrosis remains obscure. In the presenting study, we aimed …
mechanism of curcumin for liver fibrosis remains obscure. In the presenting study, we aimed …