Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

SS Patel, A Acharya, RS Ray, R Agrawal… - Critical reviews in …, 2020 - Taylor & Francis
Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …

Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy

X Cai, J Wang, J Wang, Q Zhou, B Yang, Q He… - Pharmacological …, 2020 - Elsevier
Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

A Mohammadi, CN Blesso, GE Barreto… - The Journal of nutritional …, 2019 - Elsevier
Monocytes and macrophages are important cells of the innate immune system that have
diverse functions, including defense against invading pathogens, removal of dead cells by …

Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

M Sadeghi, S Dehnavi, A Asadirad, S Xu… - …, 2023 - Springer
Chemokines belong to the family of cytokines with chemoattractant properties that regulate
chemotaxis and leukocyte migration, as well as the induction of angiogenesis and …

Molecular mechanisms of curcumin in the pathogenesis of metabolic dysfunction associated Steatotic liver disease

M Guariglia, F Saba, C Rosso, E Bugianesi - Nutrients, 2023 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial
condition characterized by insulin resistance, oxidative stress, chronic low-grade …

Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes

S Guo, X Meng, X Yang, X Liu, C Ou-Yang… - Acta Pharmacologica …, 2018 - nature.com
Cardiac fibrosis is considered the initial change of diabetic cardiomyopathy (DCM). We have
shown that curcumin alleviates collagen deposition in DCM, but the mechanism remains …

Food components with antifibrotic activity and implications in prevention of liver disease

M Bae, YK Park, JY Lee - The Journal of Nutritional Biochemistry, 2018 - Elsevier
Increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in parallel with the obesity
epidemic has been a major public health concern. NAFLD is the most common chronic liver …

A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids

X Pan, X Ma, Y Jiang, J Wen, L Yang… - Evidence‐based …, 2020 - Wiley Online Library
Liver fibrosis resulting from continuous long‐term hepatic damage represents a heavy
burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with …

Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial

M Nouri‐Vaskeh, A Malek Mahdavi… - Phytotherapy …, 2020 - Wiley Online Library
Recent reports indicated that curcumin had beneficial effects in animal models of liver injury
and cirrhosis. Current study aimed to investigate the effects of curcumin supplementation in …

[HTML][HTML] Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion

XA Zhao, G Chen, Y Liu, Y Chen, H Wu, Y Xiong… - Biomedicine & …, 2018 - Elsevier
Curcumin has been reported to have anti-fibrotic effect. However, the anti-fibrotic
mechanism of curcumin for liver fibrosis remains obscure. In the presenting study, we aimed …