Fentanyl for breakthrough pain: a systematic review

MP Davis - Expert review of neurotherapeutics, 2011 - Taylor & Francis
The purpose of this article is to systematically review the use of fentanyl as an analgesic for
breakthrough pain. This article found that the oral transmucosal fentanyl (OTFC) had a …

Cultivation of RPMI 2650 cells as an in-vitro model for human transmucosal nasal drug absorption studies: optimization of selected culture conditions

S Reichl, K Becker - Journal of Pharmacy and Pharmacology, 2012 - academic.oup.com
Objectives The kinetics of drug absorption for nasally administered drugs are often studied
using excised mucosal tissue. To avoid the disadvantages of animal experiments, cellular in …

The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1—Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line

S Bendas, EV Koch, K Nehlsen, T May, A Dietzel… - Pharmaceutics, 2023 - mdpi.com
In recent years, there has been a significant increase in the registration of drugs for nasal
application with systemic effects. Previous preclinical in vitro test systems for transmucosal …

Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using …

D Mukherjee, M Collins, DE Dylla, J Kaur… - Infectious Diseases and …, 2023 - Springer
Introduction An unsafe injection practice is one of the major contributors to new hepatitis C
virus (HCV) infections; thus, people who inject drugs are a key population to prioritize to …

Opioid‐induced hypogonadism: pathophysiology, clinical and therapeutics review

T Antony, SY Alzaharani… - Clinical and …, 2020 - Wiley Online Library
Opioids are pivotal therapeutics in the management of escalated chronic pain (moderate–
severe). In the last two decades, the increased prescription rate and the prolonged usage of …

Intranasal fentanyl in the treatment of acute pain–a systematic review

MS Hansen, O Mathiesen, S Trautner… - Acta …, 2012 - Wiley Online Library
Due to its non‐invasive mode of administration, intranasal (IN) application of drugs may be a
valuable alternative to non‐invasive pain management. With characteristics that appear to …

Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications

I Panagiotou, K Mystakidou - Expert review of anticancer therapy, 2010 - Taylor & Francis
Fentanyl, a short-acting synthetic pure opiate, offers an excellent option for the treatment of
cancer and chronic pain. While oral administration is not an option, its high potency and …

Assessment and treatment of breakthrough cancer pain: from theory to clinical practice

R Vellucci, RD Mediati, S Gasperoni… - Journal of pain …, 2017 - Taylor & Francis
Breakthrough cancer pain (BTcP) is a common condition in oncological patients. However,
its management is still suboptimal. Improved knowledge of BTcP and its management in …

Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized …

M Borland, S Milsom, A Esson - Emergency Medicine …, 2011 - Wiley Online Library
Objective: Intranasal fentanyl's (INF) effectiveness is established using highly concentrated
INF (HINF). Standard concentration INF (SINF) is more widely available. We aimed to …

Intranasal fentanyl for initial treatment of vaso‐occlusive crisis in sickle cell disease

DM Fein, JR Avner, K Scharbach… - Pediatric blood & …, 2017 - Wiley Online Library
Background Analgesia administration for children with vaso‐occlusive crises is often
delayed in the emergency department. Intranasal fentanyl (INF) has been shown to be safe …