A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular
signaling hub that, like the nervous system itself, integrates internal and external cues to …

The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Abstract mRNAs can be targeted to specific neuronal subcellular domains, which enables
rapid changes in the local proteome through local translation. This mRNA-based …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Summary PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of
damaged mitochondria through Parkin translocation and mitophagy. Because the short half …

The assembly of a new growth cone is a prerequisite for axon regeneration after injury.
Creation of a new growth cone involves multiple processes, including calcium signalling …

The complex and elaborate architecture of a neuron poses a great challenge to the cellular
machinery which localizes proteins and organelles, such as mitochondria, to necessary …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …