Saffron (Crocus sativus L.): gold of the spices—a comprehensive review

D Kothari, R Thakur, R Kumar - Horticulture, Environment, and …, 2021 - Springer
Saffron (Crocus sativus L.) is a monocotyledonous herbaceous triploid plant that produces
the most expensive spice in the world. Its main constituents, crocin, picrocrocin, and …

[HTML][HTML] Crocetin: a systematic review

ZL Guo, MX Li, XL Li, P Wang, WG Wang… - Frontiers in …, 2022 - frontiersin.org
Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological
systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several …

[HTML][HTML] Saffron and its major ingredients' effect on colon cancer cells with mismatch repair deficiency and microsatellite instability

A Amin, A Farrukh, C Murali, A Soleimani, F Praz… - Molecules, 2021 - mdpi.com
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. One
of its subtypes is associated with defective mismatch repair (dMMR) genes. Saffron has …

[HTML][HTML] Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation

Y Abdalla, A Abdalla, AA Hamza, A Amin - Frontiers in Pharmacology, 2022 - frontiersin.org
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural
products and their derived biomolecules are potential resources to mine for novel anti …

Biologically active compounds and pharmacological activities of species of the genus Crocus: A review

O Mykhailenko, V Kovalyov, O Goryacha, L Ivanauskas… - Phytochemistry, 2019 - Elsevier
The present article is the first comprehensive review on the chemical composition and
pharmacological activities of the raw materials of Crocus species. In the present review, data …

A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer's Disease

JW Finley, S Gao - Journal of agricultural and food chemistry, 2017 - ACS Publications
Alzheimer's disease (AD) is the most common form of dementia, in which the death of brain
cells causes memory loss and cognitive decline. Several factors are thought to play roles in …

[HTML][HTML] Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma

B Awad, AA Hamza, A Al-Maktoum, S Al-Salam, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Main chemical compounds and pharmacological activities of stigmas and tepals of 'red gold'; saffron

T Shahi, E Assadpour, SM Jafari - Trends in Food Science & Technology, 2016 - Elsevier
Background Crocus sativus L.(saffron) belongs to Iridaceae family which is commonly
cultivated in Asia, Europe and America. The commercial product and use of saffron comes …

[HTML][HTML] Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

A Lambrianidou, F Koutsougianni, I Papapostolou… - Molecules, 2020 - mdpi.com
Cancer is the second leading cause of death globally with an estimated 9.6 million deaths in
2018 and a sustained rise in its incidence in both developing and developed countries …

[HTML][HTML] Safranal Inhibits Angiogenesis via Targeting HIF-1α/VEGF Machinery: In Vitro and Ex Vivo Insights

A Abdalla, C Murali, A Amin - Frontiers in Oncology, 2022 - frontiersin.org
Nature has a nearly infinite inventory of unexplored phytochemicals and biomolecules that
have the potential to treat a variety of diseases. Safranal exhibits anti-cancer property and …