This microreview surveys the literature over the last five years with regard to construction of
functionalised tetrahydropyran (THP) rings in the context of the synthesis of natural products …

Functionalized tetrahydropyran (THP) rings are important building blocks and ubiquitous
scaffolds in many natural products and active pharmaceutical ingredients (API). Among …

Six-membered oxygenated heterocycles, or pyrans, are probably one of the most common
structural motifs spread across natural products, from simple glucose to structurally complex …

Allylic boron compounds have gained a prominent position as a useful class of synthetic
reagents in the past 25 years. Their general structures, 1 and 2, and their utility in carbonyl …

Herein, we present a dual catalytic strategy to efficiently obtain monoprotected homoallylic 1,
2-diols by coupling abundant aldehydes with simple (silyl) enol ethers, thus providing direct …

We describe an unusual net [2+ 2] cycloaddition reaction between boron alkylidenes and
unactivated alkenes. This reaction provides a new method for the construction of carbocyclic …

First reported in 1993 by three groups (Kobayashi and Kitagawa, Pettit, and Fusetani),[1] the
altohyrtins/spongistatins/cinachyrolides are a unique family of antimitotic macrolides [2±5] …

The completely OH-selective Prins cyclization has been realized from the enantioselective
ene reaction product. A variety of 4-hydroxyl-tetrahydropyrans were exclusively generated …

Oxygen-containing heterocycles are ubiquitous in biologically active natural products, which
can be a great source of inspiration in drug discovery. Due to the importance of this class of …

The stereoselective synthesis of carbohydrates and related bioactive compounds containing
a polyhydroxylated chain embedded in their structural framework remains a topic of great …