Molecular pathology, oxidative stress, and biomarkers in obstructive sleep apnea

PG Meliante, F Zoccali, F Cascone… - International Journal of …, 2023 - mdpi.com
Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH)
during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) …

[HTML][HTML] Recent pharmacological advances in the treatment of cardiovascular events with Astragaloside IV

Z Xu, H Zhou, Y Zhang, Z Cheng, M Wan, W Qin… - Biomedicine & …, 2023 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death and disability globally. A
wide range of CVDs have been reported, each of which diverges significantly, exhibiting …

Protective effect of Xinmai'an tablets via mediation of the AMPK/SIRT1/PGC-1α signaling pathway on myocardial ischemia-reperfusion injury in rats

W Zhang, R Chen, K Xu, H Guo, C Li, X Sun - Phytomedicine, 2023 - Elsevier
Background Xinmai'an tablets are a compound Chinese medicine comprising six traditional
Chinese medicines that have been clinically applied to treat cardiovascular diseases such …

Advances in molecular pathology of obstructive sleep apnea

M Zhang, Y Lu, L Sheng, X Han, L Yu, W Zhang, S Liu… - Molecules, 2022 - mdpi.com
Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and
set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the …

Deciphering the Efficacy and Mechanism of Astragalus membranaceus on High Altitude Polycythemia by Integrating Network Pharmacology and In Vivo Experiments

X Liu, H Zhang, J Yan, X Li, J Li, J Hu, X Shang… - Nutrients, 2022 - mdpi.com
Hypoxic exposure makes plateau migrators susceptible to high altitude polycythemia
(HAPC). Astragalus membranaceus (AM) is an edible and medicinal plant with remarkable …

Integrated transcriptomics, proteomics and metabolomics to identify biomarkers of astragaloside IV against cerebral ischemic injury in rats

X Wei, Y He, H Wan, J Yin, B Lin, Z Ding, J Yang… - Food & Function, 2023 - pubs.rsc.org
The herb Astragali Radix is a food–medicine herb. A major component of Astragali Radix,
astragaloside IV (AS-IV), has neuroprotective effects in IS, but its mechanisms are not well …

[HTML][HTML] Ginsenoside Rg1 attenuates diabetic vascular endothelial dysfunction by inhibiting the calpain-1/ROS/PKC-β axis

M Lu, F Zhao, C Ran, Y Xu, J Zhang, H Wang - Life Sciences, 2023 - Elsevier
Aims Vascular endothelial dysfunction (VED) is the onset event of cardiovascular
complications in type 2 diabetes mellitus. Ginsenoside Rg1 (Rg1) can improve the …

[HTML][HTML] Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway

C Ran, M Lu, F Zhao, Y Hao, X Guo, Y Li, Y Su… - Journal of Ginseng …, 2024 - Elsevier
Background Hypoxic pulmonary hypertension (HPH) is the main pathological change in
vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some …

Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition

H Jiang, H Wang, T Liu - Heliyon, 2023 - cell.com
Background Previous studies have demonstrated the beneficial effect of baicalin on
pulmonary arterial hypertension (PAH), but the mechanism is unclear. Aim The aim of the …

Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells

H Qi, T Ge, K Wang, J Wang, L Dang, J Li… - Cell Biochemistry and …, 2024 - Springer
Percutaneous coronary intervention (PCI) is the main treatment for patients with severe
coronary vascular stenosis. However, In-stent neo-atherosclerosis (ISNA) is an important …