We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable
associated extrapyramidal signs and symptoms, is accompanied by degeneration of the …

No treatment for frontotemporal dementia (FTD), the second most common type of early-
onset dementia, is available, but therapeutics are being investigated to target the 2 main …

Abnormal intracellular protein aggregates comprise a key characteristic in most
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …

We performed hypothesis-free linkage analysis and exome sequencing in a family with two
siblings who had neuronal ceroid lipofuscinosis (NCL). Two linkage peaks with maximum …

Frontotemporal dementia (FTD) is the second most common young-onset dementia and is
clinically characterised by progressive behavioural change, executive dysfunction and …

The aim of this study was to improve the neuropathologic recognition and provide criteria for
the pathological diagnosis in the neurodegenerative diseases grouped as frontotemporal …

Background: Frontotemporal lobar degeneration (FTLD) is a genetically and pathologically
heterogeneous neurodegenerative disorder. Methods: We collected blood samples from a …

Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a
heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have …

Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes.
Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive …