Leishmaniasis is regarded as a neglected tropical disease by World Health Organization
(WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …

Leishmania infections span a range of clinical syndromes and impact humans from many
geographic foci, but primarily the world's poorest regions. Transmitted by the bite of a female …

Inadequate and nonintegrated diagnostics are the Achilles' heel of global efforts to monitor,
control, and eradicate neglected tropical diseases (NTDs). While treatment is often …

Leishmaniases are a group of parasitic diseases transmitted through the bite of female
phlebotomine sandflies. Depending on the Leishmania species, the reservoirs can be …

Visceral leishmaniasis is a reemerging neglected tropical disease with limitations for its
diagnosis, including low concentration of antibodies in the serum of asymptomatic patients …

Here, we report the effect of new non-classical bioisosteres of miltefosine on Leishmania
amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing …

Leishmania donovani (a causative agent of visceral leishmaniasis) poses a serious health
threat to the human population which is fatal if left untreated. The life cycle of Leishmania …

Parasitic neglected tropical diseases (NTDs) affect over one billion people worldwide, with
individuals from communities in low-socioeconomic areas being most at risk and suffering …

Leishmaniasis is still a serious neglected tropical disease that may cause death in infected
individuals. At present, the clinical diagnosis and treatment monitoring still rely on …

Background Visceral leishmaniasis (VL), due to Leishmania infantum, is a persistent
intracellular parasitic infection transmitted by the bite of infected sand flies. Symptomatic VL …