Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease
(AD). To address the underlying mechanism, we develop cerebral organoid models using …

Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions
through the initiation of protein folding, repair, refolding of misfolded peptides, and possible …

Heat shock proteins (HSPs) are constitutively expressed under physiological conditions in
most organisms but their expression can significantly enhance in response to four types of …

Molecular chaperones are ubiquitous and abundant within cellular environments,
functioning as a defense mechanism against outer environment. The range of molecular …

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …

Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I
molecules with endogenous peptides during their biosynthesis within the endoplasmic …

Mutant TP53 proteins are thought to drive the development and sustained expansion of
cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive …