Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Here's your ideal reference on the diagnosis of tumors of the skeletal muscles, connective
tissue, fat, and related structures. No other textbook matches its scope and depth of …

Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic,
mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to …

Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

Melanoma is a lethal melanocytic neoplasm. Unfortunately, the histological diagnosis can
be difficult at times. Distinguishing ambiguous melanocytic neoplasms that are benign nevi …

A potential diagnostic pitfall in the histologic assessment of melanoma is the inability to
recognize unusual melanoma variants. Of these, the more treacherous examples include the …

Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic
histopathologic features, some of which are overlapping with melanoma. More common in …

Melanomas are very aggressive neoplasms with notorious resistance to therapeutics. It was
recently proposed that the remarkable phenotypic plasticity of melanoma cells allows for the …