Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Stress is a major risk factor for psychiatric disorders. During and after exposure to stressors,
the stress response may have pro-or maladaptive consequences, depending on several …

Inflammatory depression is closely related to neuroinflammation. However, current anti-
inflammatory drugs have low permeability to cross blood–brain barrier with difficulties …

Background A growing body of research shows that drug monomers from traditional
Chinese herbal medicines have antineuroinflammatory and neuroprotective effects that can …

Major depressive disorder (MDD) is a psychiatric disorder with increasing prevalence
worldwide. It is a leading cause of disability and suicide, severely affecting physical and …

Extracellular vesicles (EVs) are nanoscale particles with various physiological functions
including mediating cellular communication in the central nervous system (CNS), which …

Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …

Abstract Purpose Saikosaponin C (SSc) increases the expression of synaptic proteins and
has a unexplored role in the prevention of AD and other neurodegeneration in humans …

Major depressive disorder (MDD) is a serious mental disease characterized by depressed
mood, loss of interest and suicidal ideation. Its rising prevalence has rendered MDD one of …

The field of neuropsychiatry is considered a middle ground between neurological and
psychiatric disorders, thereby bridging the conventional boundaries between matter and …