The treatment and management of neuroleptic-resistant schizophrenic patients, who
comprise 5 to 25 percent of all patients with that diagnosis, are major problems for …

It is no longer tenable to attribute all the antipsychotic action of antipsychotic drugs to
dopamine (DA) D2 receptor blockade and subsequent development of depolarization …

A series of phthalimide and isoindolinone derivatives bridged to 4-(1, 2-benzisothiazol-3-yl)-
1-piperazinyl was prepared. The compounds were evaluated in vitro at dopamine D2 and …

In previous studies, several isoindolin-1-one analogs that exhibited significant anti-tobacco
mosaic virus (anti-TMV) activities were isolated from Nicotiana tabacum. Since gene-editing …

Background Many people with schizophrenia do not achieve a satisfactory treatment
response with just antipsychotic drug treatment and various adjunct medications are used to …

Clozapine can produce greater clinical improvement in both positive and negative
symptoms than typical antipsychotic drugs in neuroleptic-resistant schizophrenic patients …

The question of whether schizophrenia is associated with structural or functional
abnormalities of the nervous system, or both, has become the principal focus of biological …

An efficient, one-pot and four-component synthesis of a new series of 2, 3-disubstituted
isoindolin-1-ones is described and their Jack bean urease inhibitory activities are evaluated …

A series of novel isoindoline-1-one derivatives containing piperidine moiety were designed
and synthesized using natural compounds as raw materials, and their biological activities …

Objectives: The aims of the paper are to review the notion of treatment resis-tance in
schizophrenia and consider the factors important in determining non-responsiveness to …