Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
The autophagy–NAD axis in longevity and disease
Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
Recent advances in targeting autophagy in cancer
Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …
Roles of NAD+ in Health and Aging
NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …
Temozolomide, simvastatin and acetylshikonin combination induces mitochondrial-dependent apoptosis in GBM cells, which is regulated by autophagy
Simple Summary Glioblastoma multiforme (GBM) is a deadly brain tumor. The current
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
Autophagy is a homeostatic process critical for cellular survival, and its malfunction is
implicated in human diseases including neurodegeneration. Loss of autophagy contributes …
implicated in human diseases including neurodegeneration. Loss of autophagy contributes …
Adipose mesenchymal stem cell-derived exosomes promote skin wound healing in diabetic mice by regulating epidermal autophagy
H Ren, P Su, F Zhao, Q Zhang, X Huang, C He… - Burns & …, 2024 - academic.oup.com
Background Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great
potential in the field of tissue repair and regenerative medicine, particularly in cases of …
potential in the field of tissue repair and regenerative medicine, particularly in cases of …
Modulation of mitochondrial function as a therapeutic strategy for neurodegenerative diseases
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer's Disease, strategies
that target early molecular mechanisms and could delay or change the disease trajectory …
that target early molecular mechanisms and could delay or change the disease trajectory …
The evolution of selective autophagy as a mechanism of oxidative stress response: The evolutionarily acquired ability of selective autophagy receptors to respond to …
Ageing is associated with a decline in autophagy and elevated reactive oxygen species
(ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can …
(ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can …
Quercetin inhibits necroptosis in cardiomyocytes after ischemia–reperfusion via DNA‐PKcs‐SIRT5‐orchestrated mitochondrial quality control
X Chang, Q Zhang, Y Huang, J Liu… - Phytotherapy …, 2024 - Wiley Online Library
We investigated the mechanism by which quercetin preserves mitochondrial quality control
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …