Biomarkers for Managing Neurodegenerative Diseases
Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …
Protein aggregation and therapeutic strategies in SOD1-and TDP-43-linked ALS
M Tsekrekou, M Giannakou… - Frontiers in Molecular …, 2024 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with severe socio-
economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic …
economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic …
Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
JL Robinson, ER Suh, Y Xu, HI Hurtig, L Elman… - Acta …, 2024 - Springer
Abstract TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein found within
ribonucleoprotein granules tethered to lysosomes via annexin A11. TDP-43 protein forms …
ribonucleoprotein granules tethered to lysosomes via annexin A11. TDP-43 protein forms …
Proteomic analysis of the TDP-43-associated insoluble fraction from NEFH-TDP-43 mouse brain suggests sustained stress granule formation, CLUH granule …
F Dunlop, S Mason, S Tsitaknou, AP Russell - bioRxiv, 2024 - biorxiv.org
Cytoplasmic accumulation and aggregation of TDP-43 is a hallmark of~ 97% of ALS cases.
Formation of TDP-43 insoluble aggregates is suggested to either directly or indirectly cause …
Formation of TDP-43 insoluble aggregates is suggested to either directly or indirectly cause …
The current economics and throughput of single cell proteomics by liquid chromatography mass spectrometry
A Smythers, B Orsburn - 2024 - chemrxiv.org
Single cell proteomics by mass spectrometry (SCP) is an emerging field of study that has
captured the interest and imagination of biologists in a wide array of disciplines. In the …
captured the interest and imagination of biologists in a wide array of disciplines. In the …
Advancing Single-Cell Proteomics Through Innovations in Liquid Chromatography and Mass Spectrometry
KGI Webber - 2024 - scholarsarchive.byu.edu
Traditional proteomics studies can measure many protein biomarkers simultaneously from a
single patient-derived sample, promising the possibility of syndromic diagnoses of multiple …
single patient-derived sample, promising the possibility of syndromic diagnoses of multiple …