Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

A model is proposed for the mechanism by which activation of surface membrane receptors
causes sustained Ca 2+ entry into cells from the extracellular space. Reassessment of …

There has recently been rapid progress in understanding receptors that generate
intracellular signals from inositol lipids. One of these lipids, phosphatidylinositol 4, 5 …

Activation of receptors for a wide variety of hormones and neurotransmitters leads to an
increase in the intracellular level of calcium. Much of this calcium is released from …

Protein kinase C has a crucial role in signal transduction for a variety of biologically active
substances which activate cellular functions and proliferation. When cells are stimulated …

Tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA)
directly activate in vitro Ca2+-activated, phospholipid-dependent protein kinase (protein …

Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol
trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that …