The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Introduction In the time of increasing resistance and paucity of new drug development there
is a growing need for strategies to enhance rational use of antibiotics in German and …

Background Meropenem exhibits time-dependent antimicrobial activity and prolonged
infusion (PI)(extended infusion or continuous infusion, EI or CI) of meropenem can better …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and
aggressive interventions are essential for improving clinical outcomes. There are a number …

Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections
because of their wide spectrum of activity and low toxicity. Since resistance rates among …

Mortality and morbidity in severe sepsis and septic shock remain high despite significant
advances in critical care. Efforts to improve outcome in septic conditions have focused on …