Statin drug interactions and related adverse reactions: an update
S Bellosta, A Corsini - Expert opinion on drug safety, 2018 - Taylor & Francis
Introduction: Statins reduce the risk of cardiovascular morbidity and mortality in patients with
or at risk for cardiovascular disease and their use is expanding, especially in elderly. Statins …
or at risk for cardiovascular disease and their use is expanding, especially in elderly. Statins …
Regulation of cholesterol homeostasis
MYM van der Wulp, HJ Verkade, AK Groen - Molecular and cellular …, 2013 - Elsevier
Hypercholesterolemia is an important risk factor for cardiovascular disease. It is caused by a
disturbed balance between cholesterol secretion into the blood versus uptake. The …
disturbed balance between cholesterol secretion into the blood versus uptake. The …
Drug‐induced liver injury: The role of drug metabolism and transport
A Corsini, M Bortolini - The journal of clinical pharmacology, 2013 - Wiley Online Library
Many studies have pinpointed the significant contribution of liver‐mediated drug metabolism
and transport to the complexity of drug‐induced liver injury (DILI). Phase I cytochrome P450 …
and transport to the complexity of drug‐induced liver injury (DILI). Phase I cytochrome P450 …
Statin induced myotoxicity
S Sathasivam - European journal of internal medicine, 2012 - Elsevier
Statins are an effective treatment for the prevention of cardiovascular diseases and used
extensively worldwide. However, myotoxicity induced by statins is a common adverse event …
extensively worldwide. However, myotoxicity induced by statins is a common adverse event …
Statin drug interactions and related adverse reactions
S Bellosta, A Corsini - Expert opinion on drug safety, 2012 - Taylor & Francis
Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse
events. The most important adverse effects associated with statins are myopathy and an …
events. The most important adverse effects associated with statins are myopathy and an …
The Role of n-3 Long Chain Polyunsaturated Fatty Acids in Cardiovascular Disease Prevention, and Interactions with Statins
Decreases in global cardiovascular disease (CVD) mortality and morbidity in recent
decades can be partly attributed to cholesterol reduction through statin use. n-3 long chain …
decades can be partly attributed to cholesterol reduction through statin use. n-3 long chain …
Synthetic approaches to contemporary drugs that contain the cyclopropyl moiety
Z Časar - Synthesis, 2020 - thieme-connect.com
The US Food and Drug Administration approved 18 new drugs that incorporate the
cyclopropyl structural motif in the time frame from 2012 to 2018. This review provides an …
cyclopropyl structural motif in the time frame from 2012 to 2018. This review provides an …
Pleiotropic effects of pitavastatin
J Davignon - British journal of clinical pharmacology, 2012 - Wiley Online Library
3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors (statins) are
established first line treatments for hypercholesterolaemia. In addition to the direct effects of …
established first line treatments for hypercholesterolaemia. In addition to the direct effects of …
Safety of statins: an update
M Hu, BMY Cheung… - Therapeutic advances in …, 2012 - journals.sagepub.com
Statins are widely used and have been proven to be effective in the prevention of
atherosclerotic vascular disease events, primarily by reducing plasma low-density …
atherosclerotic vascular disease events, primarily by reducing plasma low-density …
Muscular effects of statins in the elderly female: a review
S Bhardwaj, S Selvarajah… - Clinical interventions in …, 2013 - Taylor & Francis
Statins have demonstrated substantial benefits in supporting cardiovascular health. Older
individuals are more likely to experience the well-known muscle-related side effects of …
individuals are more likely to experience the well-known muscle-related side effects of …