Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), a chronic
inflammatory state that can progress through a series of transformative dysplastic states …

The emergence and clinical application of immunotherapy is considered a promising
breakthrough in cancer treatment. According to the literature, immune checkpoint blockade …

Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-
oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment …

BACKGROUND. Myeloid-derived suppressor cells (MDSCs) are a population of immature
immune cells with several protumorigenic functions. CD38 is a transmembrane receptor …

A purified polysaccharide nCKAP-2 was prepared from Curcuma kwangsiensis and
characterized. Structural analyses revealed that nCKAP-2 contains a high-branched …

Myeloid-derived suppressor cells (MDSCs) are key player in mediating systemic
immunosuppression, and their accumulation and expansion in the periphery and tumor …

In recent years, an increasing number of studies have shown that there is an important
connection between nitric oxide (NO) and the pathology of malignant diseases, but we are …

Background: Hepatocellular carcinoma (HCC) is the 3rd most common cause of cancer-
related death worldwide. It has evolved different immune escape mechanisms, which might …

Toll-like receptors (TLRs) are an evolutionarily conserved group of enzymatically inactive,
single membrane-spanning proteins that recognize a wide panel of exogenous and …

In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous
studies have shown that circulating and infiltrating neutrophils are associated with malignant …