Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Renal-clearable and target-responsive near-infrared (NIR) fluorescent imaging probes have
been promising for in vivo diagnosis of acute kidney injury (AKI). However, designing an …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Acute kidney injury (AKI) can lead to loss of kidney function and a substantial increase in
mortality. The burst of reactive oxygen species (ROS) plays a key role in the pathological …

Acute kidney injury (AKI), a common and serious clinical kidney syndrome with high
incidence and mortality, is caused by multiple pathogenic factors, such as ischemia …

In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …