Background Muscle cramps can occur anywhere and for many reasons. Quinine has been
used to treat cramps of all causes. However, controversy continues about its efficacy and …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading
to generalized muscle weakness and premature death. Sleep disturbances are extremely …

Abstract Purpose of Review: This article provides an update on six sleep-related movement
disorders: restless legs syndrome (RLS), periodic limb movement disorder, sleep-related leg …

OBJECTIVE This article reviews common sleep-related movement disorders, including their
clinical description, epidemiology, pathophysiology (if known), and evaluation and …

Background Up to 33% of the general population over 50 years of age are affected by
nocturnal leg cramps. Currently there are no generally accepted clinical characteristics …

Nocturnal leg cramps are common and troublesome, especially in later life, and have a
significant impact on quality of life, particularly sleep quality. This article reviews the current …

Background Cramps are involuntary painful muscle contractions that mainly affect older
people. Cramps may cause severe pain and sleep disturbance. Little information exists on …

Background Clinical trial registration has become an important part of editorial policies of
various biomedical journals, including a few physical therapy journals. However, the extent …

Background Chronic venous insufficiency (CVI) causes pathophysiological changes in the
lower-limb muscles, particularly the calf muscles, and limits ankle range of motion (ROM) …

Background and purpose The frequency of pain and cramps is uncertain in anti‐myelin
associated glycoprotein antibody (anti‐MAG) neuropathy. Whether these symptoms may …