The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

Abstract Pro-opiomelanocortin (POMC)-and agouti-related peptide (AgRP)-expressing
neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by …

Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …

Ghrelin, a circulating growth hormone–releasing peptide derived from the stomach,
stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was …

Induction of beige cells causes the browning of white fat and improves energy metabolism.
However, the central mechanism that controls adipose tissue browning and its physiological …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

Obesity represents the most prevalent nutritional problem worldwide which in the long run
predisposes to development of diabetes mellitus, hypertension, endometrial carcinoma …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

Energy homeostasis is controlled by a complex neuroendocrine system consisting of
peripheral signals like leptin and central signals, in particular, neuropeptides. Several …