Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites

R Rani, K Sethi, S Kumar, RS Varma… - Chemical Biology & …, 2022 - Wiley Online Library
Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Phytochemical profile and diverse pharmacology of Garcinia celebica L.

NH Mustafa, J Jalil, KE Leong, JA Jamal, K Husain - Heliyon, 2024 - cell.com
Garcinia celebica L. syn. Garcinia hombroniana Pierre belongs to the family Clusiaceae, is
indigenous to Southeast Asian countries. This review aims to provide updated …

Naphthoquinone derivatives exhibit apoptosis-like effect and anti-trypanosomal activity against Trypanosoma evansi

R Rani, B Narasimhan, RS Varma, R Kumar - Veterinary Parasitology, 2021 - Elsevier
Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …

Chitosan quinapyramine sulfate nanoparticles exhibit increased trypanocidal activity in mice

A Manuja, N Dilbaghi, H Kaur, R Saini… - Nano-Structures & Nano …, 2018 - Elsevier
An aminoquinaldine derivative, quinapyramine sulfate (QS) is the commonly used and
effective drug for treatment of Trypanosoma evansi infection. It produces the trypanocidal …

First outbreak of autochthonous “surra” in horses in Santa Catarina State, Brazil: Parasitological, hematological and biochemical characteristics

C Reck, Á Menin, NL Pisetta, F Batista… - … : Regional Studies and …, 2020 - Elsevier
This study reports the first autochthonous “surra” outbreak in horses in the State of Santa
Catarina, southern Brazil. Six horses with clinical suspicion of trypanosomosis had the …

β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A2: in vitro kinetic analyses and molecular dynamic simulations

S Aminu, AU Danazumi, ZA Alhafiz, MW Gorna… - Molecular Diversity, 2023 - Springer
The involvement of Trypanosoma congolense sialidase alongside phospholipase A2 has
been widely accepted as the major contributing factor to anemia during African animal …

Chemotherapeutic control of trypanosomosis-a review of past measures, current status and future trends

KI Eghianruwa, OA Oridupa - Veterinarski arhiv, 2018 - hrcak.srce.hr
Sažetak African trypanosomosis is a major parasitic disease which affects both humans and
animals in the Africa continent, south of the Sahara desert. It is caused by infection with …

Hematobiochemical and Immunological Responses of Rats Treated with Multi-strain Probiotics and Infected with Trypanosoma brucei

CC Okolo, NE Nweze, IJ Eze - Probiotics and antimicrobial proteins, 2020 - Springer
The effects of treatment with probiotics on the immunological and hematobiochemical
changes in Trypanosoma brucei infection were investigated. Probiotic strains used are …

Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells

S Singh, B Kumar, N Dilbaghi, N Devi, M Prasad… - Journal of …, 2023 - mdpi.com
Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use
against vector-borne animal trypanosomosis (mainly Surra caused by Trypanosoma evansi) …

Biocompatibility and targeting efficiency of encapsulated quinapyramine sulfate-loaded chitosan-mannitol nanoparticles in a rabbit model of surra

A Manuja, B Kumar, R Kumar, M Chopra… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Quinapyramine sulfate (QS) produces trypanocidal effects against the parasite
Trypanosoma evansi but is often poorly tolerated and causes serious reactions in animals …