Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Macrophages are effector cells of the innate immune system that phagocytose bacteria and
secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play …

Apoptosis and the clearance of apoptotic cells are essential processes in animal
development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat …

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …