The RNA-binding protein HuR in human cancer: A friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
Regulation of cytoplasmic mRNA decay
DR Schoenberg, LE Maquat - Nature Reviews Genetics, 2012 - nature.com
Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …
means of modulating gene expression and thereby protein production. Up until recently …
[HTML][HTML] A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
Posttranslational control of HuR function
I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …
coding and noncoding, and controls their splicing, localization, stability, and translation …
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer
Y Lan, X Xiao, Z He, Y Luo, C Wu, L Li… - Nucleic acids …, 2018 - academic.oup.com
Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long
noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains …
noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains …
[HTML][HTML] HuR function in disease
S Srikantan, M Gorospe - Frontiers in bioscience (Landmark edition …, 2012 - ncbi.nlm.nih.gov
The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …
and translation, potently influence the cellular response to internal and external signals. The …
[HTML][HTML] Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis
J Wang, Y Guo, H Chu, Y Guan, J Bi… - International journal of …, 2013 - mdpi.com
The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …
Posttranscriptional regulation of cancer traits by HuR
K Abdelmohsen, M Gorospe - Wiley Interdisciplinary Reviews …, 2010 - Wiley Online Library
Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …
HuR as a molecular target for cancer therapeutics and immune-related disorders
M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
The function of the vast majority of mammalian long noncoding (lnc) RNAs remains
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …