Melatonin: A novel candidate for the treatment of osteoarthritis

Y Zhang, T Liu, H Yang, F He, X Zhu - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

RJ Reiter, R Sharma, F Simko… - Cellular and Molecular …, 2022 - Springer
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

Translational and clinical applications of dental stem cell-derived exosomes

Z Mai, H Chen, Y Ye, Z Hu, W Sun, L Cui… - Frontiers in genetics, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration
due to their featured properties of self-renewal and multipotency. However, a growing body …

Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy

S Zhang, L Wang, Y Kang, J Wu, Z Zhang - Acta Biomaterialia, 2023 - Elsevier
Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …

Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis

Y Zhang, M Hou, Y Liu, T Liu, X Chen… - Journal of Pineal …, 2022 - Wiley Online Library
Recent evidence indicates that the mitochondrial functions of chondrocytes are impaired in
the pathogenesis of osteoarthritis (OA). Melatonin can attenuate cartilage degradation …

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

Y Jin, Z Liu, Z Li, H Li, C Zhu, R Li, T Zhou… - International journal of …, 2022 - nature.com
Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies.
Aberrant mechanical stimuli was demonstrated to be an essential factor for OA …

TET1 Regulates Skeletal Stem–Cell Mediated Cartilage Regeneration

A Pandey, M Hoover, M Singla, Y Bedi… - Arthritis & …, 2024 - Wiley Online Library
Objective Adult skeletal stem cells (SSCs) that give rise to chondrocytes, osteocytes, and
stromal cells as progeny have been shown to contribute to cartilage regeneration in …

Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review

KH Lu, PWA Lu, CW Lin, EWH Lu, SF Yang - Matrix Biology, 2023 - Elsevier
Osteoarthritis (OA), the most common form of arthritis, is characterized by progressive
cartilage destruction, concomitant adaptive osteogenesis, and loss of joint function. The …

Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular …

I Ozturk, H Elbe, Y Bicer, M Karayakali, MO Onal… - Food and Chemical …, 2023 - Elsevier
Acrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it
could be a carcinogen in humans and rodents. The purpose of the current study was to …

Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression

HC Tai, SW Wang, S Swain, LW Lin… - Journal of pineal …, 2022 - Wiley Online Library
Advanced prostate cancer often develops into bone metastasis, which is characterized by
aberrant bone formation with chronic pain and lower chances of survival. No treatment exists …