Melatonin: A novel candidate for the treatment of osteoarthritis
Y Zhang, T Liu, H Yang, F He, X Zhu - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
Translational and clinical applications of dental stem cell-derived exosomes
Z Mai, H Chen, Y Ye, Z Hu, W Sun, L Cui… - Frontiers in genetics, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration
due to their featured properties of self-renewal and multipotency. However, a growing body …
due to their featured properties of self-renewal and multipotency. However, a growing body …
Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy
S Zhang, L Wang, Y Kang, J Wu, Z Zhang - Acta Biomaterialia, 2023 - Elsevier
Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis
Y Zhang, M Hou, Y Liu, T Liu, X Chen… - Journal of Pineal …, 2022 - Wiley Online Library
Recent evidence indicates that the mitochondrial functions of chondrocytes are impaired in
the pathogenesis of osteoarthritis (OA). Melatonin can attenuate cartilage degradation …
the pathogenesis of osteoarthritis (OA). Melatonin can attenuate cartilage degradation …
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1
Y Jin, Z Liu, Z Li, H Li, C Zhu, R Li, T Zhou… - International journal of …, 2022 - nature.com
Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies.
Aberrant mechanical stimuli was demonstrated to be an essential factor for OA …
Aberrant mechanical stimuli was demonstrated to be an essential factor for OA …
TET1 Regulates Skeletal Stem–Cell Mediated Cartilage Regeneration
Objective Adult skeletal stem cells (SSCs) that give rise to chondrocytes, osteocytes, and
stromal cells as progeny have been shown to contribute to cartilage regeneration in …
stromal cells as progeny have been shown to contribute to cartilage regeneration in …
Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review
KH Lu, PWA Lu, CW Lin, EWH Lu, SF Yang - Matrix Biology, 2023 - Elsevier
Osteoarthritis (OA), the most common form of arthritis, is characterized by progressive
cartilage destruction, concomitant adaptive osteogenesis, and loss of joint function. The …
cartilage destruction, concomitant adaptive osteogenesis, and loss of joint function. The …
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular …
Acrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it
could be a carcinogen in humans and rodents. The purpose of the current study was to …
could be a carcinogen in humans and rodents. The purpose of the current study was to …
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression
HC Tai, SW Wang, S Swain, LW Lin… - Journal of pineal …, 2022 - Wiley Online Library
Advanced prostate cancer often develops into bone metastasis, which is characterized by
aberrant bone formation with chronic pain and lower chances of survival. No treatment exists …
aberrant bone formation with chronic pain and lower chances of survival. No treatment exists …