Pertussis is a respiratory infectious disease that has been resurged during the last decades.
The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular …

Effective diphtheria, tetanus toxoids, whole-cell pertussis (wP) vaccines were used for
massive immunization in the 1950s. The broad use of these vaccines significantly reduced …

Neuromuscular diseases (NMDs) encompass a broad spectrum of conditions. Because
infections may be relevant to the final prognosis of most NMDs, vaccination appears to be …

There is limited information on the roles of different age groups during pertussis outbreaks.
Little is known about vaccine effectiveness against pertussis infection (both clinically …

Objectives. We examined the impact of undetected infections, adult immunity, and waning
vaccine-acquired immunity on recent age-related trends in pertussis incidence. Methods …

Abstract Currently, the Advisory Committee on Immunization Practices recommends one-
time tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination for …

Background One common observation in infectious diseases caused by multi-strain
pathogens is that both the incidence of all infections and the relative fraction of infection with …

Notifications of infant deaths, assumed to be related to the introduction of new pentavalent
DTwP-Hib-HBV childhood vaccines, caused, during 2008–2010 in few Asian countries …

Whooping cough is a respiratory infection with a severity that varies with age, immune
status, and probably with other factors such as the degree of exposure and the virulence of …

En este trabajo de tesis hemos abordado el diseño de diferentes formulaciones vacunales
con el objetivo de hacer frente a una enfermedad respiratoria inmunoprevenible que ha …