Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders

C Muehlan, C Vaillant, I Zenklusen… - Expert opinion on …, 2020 - Taylor & Francis
Introduction The last two decades have witnessed a rapid increase in the knowledge about
the role of the orexin system, particularly in the regulation of wakefulness and arousal. Dual …

The role of artificial intelligence in the treatment of obstructive sleep apnea

HL Brennan, SD Kirby - Journal of Otolaryngology-Head & …, 2023 - journals.sagepub.com
Background The first-line and most common treatment for obstructive sleep apnea is nasal
continuous positive airway pressure, which serves as a pneumatic splint to stabilize the …

[HTML][HTML] Obstructive Sleep Apnea, Metabolic Dysfunction, and Periodontitis—Machine Learning and Statistical Analyses of the Dental, Oral, Medical Epidemiological …

N Ytzhaik, D Zur, C Goldstein, G Almoznino - Metabolites, 2023 - mdpi.com
This study aimed to analyze the associations of obstructive sleep apnea (OSA) with dental
parameters while controlling for socio-demographics, health-related habits, and each of the …

[HTML][HTML] Clinical and research solutions to manage obstructive sleep apnea: a review

F Xia, M Sawan - Sensors, 2021 - mdpi.com
Obstructive sleep apnea (OSA), a common sleep disorder disease, affects millions of
people. Without appropriate treatment, this disease can provoke several health-related risks …

[HTML][HTML] Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling …

F Zhao, Y Meng, Y Wang, S Fan, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep
apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has …

[HTML][HTML] An exploratory study on the association between serotonin and sleep breathing disorders

M Wieckiewicz, H Martynowicz, G Lavigne… - Scientific Reports, 2023 - nature.com
This exploratory observational study aimed to evaluate whether the blood levels of serotonin
and enzymes involved in serotonin synthesis are associated with sleep breathing …

[HTML][HTML] An Update on Obstructive Sleep Apnea Syndrome—A Literature Review

AL Platon, CG Stelea, O Boișteanu, E Patrascanu… - Medicina, 2023 - mdpi.com
Obstructive sleep apnea syndrome (OSAS) is the most common breathing-related sleep
disorder. It is characterized by recurrent episodes of partial or complete airway obstruction …

Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway

J Si, B Liu, K Qi, X Chen, D Li, S Yang, E Ji - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Chronic intermittent hypoxia (CIH) is the primary
pathophysiological process of obstructive sleep apnea (OSA) and is closely linked to …

[HTML][HTML] Socio-ecological context of sleep: gender differences and couples' relationships as exemplars

AN Decker, AR Fischer, HE Gunn - Current Psychiatry Reports, 2022 - Springer
Abstract Purpose of Review We summarized recent findings on insufficient sleep and
insomnia, two prominent sleep issues that impact public health. We demonstrate the socio …

[HTML][HTML] Assessment of Alzheimer's disease-related biomarkers in patients with obstructive sleep apnea: A systematic review and meta-analysis

W Cui, Z Duan, Z Li, J Feng - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Increasing evidence links Alzheimer's disease (AD) to various sleep disorders, including
obstructive sleep apnea (OSA). The core AD cerebrospinal fluid (CSF) biomarkers including …