Th17 cells remain one of the most important subsets of T cells in numerous autoimmune and
chronic inflammatory diseases. Posttranscriptional regulation (PTR), especially mRNA …

Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of
inflammation-related proteins by binding to the targeted AU-rich element in the …

Productive transmission of malaria parasites hinges upon the execution of key
transcriptional and posttranscriptional regulatory events. While much is now known about …

Members of the tristetraprolin (TTP) family of RNA-binding proteins can bind to and promote
the decay of specific transcripts containing AU-rich motifs. ZFP36 (TTP) is best known for …

Innate lymphoid cells (ILCs) are important subsets of innate immune cells that regulate
mucosal immunity. ILCs include natural killer cells, innate lymphoid cells-1 (ILC1s), ILC2s …

Eukaryotic gene expression can be spatiotemporally tuned at the post-transcriptional level
by cis-regulatory elements in mRNA sequences. An important example is the AU-rich …

CCCH-type zinc figure proteins (ZFP) are small cellular proteins that are structurally
maintained by zinc ions. Zinc ions coordinate the protein structure in a tetrahedral geometry …

Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-
finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is …

Post-transcriptional processes mediated by mRNA binding proteins represent important
control points in gene expression. In eukaryotes, mRNAs containing specific AU-rich motifs …

Abnormal regulation of pro-inflammatory cytokine and chemokine mediators can contribute
to the excess inflammation characteristic of many autoimmune diseases, such as …