Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment
Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …
[HTML][HTML] Mismatch repair pathway, genome stability and cancer
The acquisition of genomic instability is one of the key characteristics of the cancer cell, and
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …
Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno …
S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …
implications of this response are increasingly recognized, and as immunotherapies are …
The consensus molecular subtypes of colorectal cancer
Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and
drug responses. To resolve inconsistencies among the reported gene expression–based …
drug responses. To resolve inconsistencies among the reported gene expression–based …
[HTML][HTML] Immunotherapy of colorectal cancer: Challenges for therapeutic efficacy
D Ciardiello, PP Vitiello, C Cardone, G Martini… - Cancer treatment …, 2019 - Elsevier
A better knowledge of the complex interactions between cancer cells and the immune
system has led to novel immunotherapy approaches. Treatment with selective anti-PD1, anti …
system has led to novel immunotherapy approaches. Treatment with selective anti-PD1, anti …
[HTML][HTML] Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in colorectal cancer
Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …
Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
S Venderbosch, ID Nagtegaal, TS Maughan… - Clinical Cancer …, 2014 - AACR
Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR)
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …
Mismatch repair deficiency: The what, how and why it is important
The mismatch repair system is a major pathway that functions in the maintenance of
genomic integrity. It is involved in mitotic and meiotic recombination, apoptosis …
genomic integrity. It is involved in mitotic and meiotic recombination, apoptosis …
S3-leitlinie–kolorektales karzinom
W Schmiegel, B Buchberger… - Zeitschrift für …, 2017 - thieme-connect.com
2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …
Validation of microsatellite instability detection using a comprehensive plasma-based genotyping panel
J Willis, MI Lefterova, A Artyomenko, PM Kasi… - Clinical Cancer …, 2019 - AACR
Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using
cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using …
cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using …