Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980,
hedgehog (Hh) signaling has been implicated in regulation of cell differentiation …

Background: Signaling from integrins and receptor tyrosine kinases (RTKs) contributes
substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 …

Intrinsic tumor resistance to radiotherapy limits the efficacy of ionizing radiation (IR).
Sensitizing cancer cells specifically to IR would improve tumor control and decrease normal …

Cervical cancer is the fourth most commonly diagnosed cancer and the fourth leading cause
of cancer death in women worldwide. Approximately half of cervical cancer patients present …

Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes.
To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing …

Simple Summary Hypoxia is found in half of the solid cancers and is a major contributor to
treatment resistance and promotion of metastasis, leading to shortened patient survival. No …

The most successful therapeutic strategies for locally advanced cancers continue to
combine decades-old classical radiosensitizing chemotherapies with radiotherapy …

MDM2–p53 interaction and downstream signaling affect cellular response to DNA damage.
AMG 232 is a potent small molecule inhibitor that blocks the interaction of MDM2 and p53 …

Colorectal cancer (CRC) represents a major public health problem as the second leading
cause of cancer‐related mortality in the United States. Of an estimated 140,000 newly …