Context-dependent role of SIRT3 in cancer
J Zhang, J Ye, S Zhu, B Han, B Liu - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Sirtuin 3 (SIRT3), an NAD+-dependent deacetylase, plays a key role in the
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …
NAD+ metabolism-based immunoregulation and therapeutic potential
J Fang, W Chen, P Hou, Z Liu, M Zuo, S Liu, C Feng… - Cell & Bioscience, 2023 - Springer
Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …
Identidication of novel biomarkers in non-small cell lung cancer using machine learning
F Wang, Q Su, C Li - Scientific Reports, 2022 - nature.com
Lung cancer is one of the leading causes of cancer-related deaths worldwide, and non-
small cell lung cancer (NSCLC) accounts for a large proportion of lung cancer cases, with …
small cell lung cancer (NSCLC) accounts for a large proportion of lung cancer cases, with …
Insights into regulators of p53 acetylation
M Nagasaka, C Miyajima, H Aoki, M Aoyama… - Cells, 2022 - mdpi.com
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of
target genes and diverse physiological processes. To precisely regulate the p53 network …
target genes and diverse physiological processes. To precisely regulate the p53 network …
Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing
Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations
in cancer cells; however, most genomic regions sequenced in single cells are non …
in cancer cells; however, most genomic regions sequenced in single cells are non …
AMDHD1 acts as a tumor suppressor and contributes to activation of TGF-β signaling pathway in cholangiocarcinoma
Z Ma, J Sun, Z Li, S Huang, B Li - Cell Death & Differentiation, 2024 - nature.com
Cholangiocarcinoma (CCA) is a malignant tumor of the digestive system, characterized by
its aggressive behavior and the absence of effective therapeutic biomarkers. Although …
its aggressive behavior and the absence of effective therapeutic biomarkers. Although …
[HTML][HTML] ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter …
X Wang, L Yao, Z Li, J Zhang, M Ruan… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Background: Renal cell carcinoma (RCC) is one of the most common malignant tumours of
the urinary system. However, the aetiology and pathogenesis of RCC remain unclear. The …
the urinary system. However, the aetiology and pathogenesis of RCC remain unclear. The …
FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway
X Hu, S Zhou, H Li, Z Wu, Y Wang, L Meng… - Cancer Cell …, 2023 - Springer
Background Drug resistance is a main factor affecting the chemotherapy efficacy of gastric
cancer (GC), in which meiosis plays an important role. Therefore, it is urgent to explore the …
cancer (GC), in which meiosis plays an important role. Therefore, it is urgent to explore the …
[HTML][HTML] Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies
H Shen, W Ma, Y Hu, Y Liu, Y Song, L Fu, Z Qin - Theranostics, 2024 - ncbi.nlm.nih.gov
The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …
Zinc remodels mitochondrial network through SIRT3/Mfn2-dependent mitochondrial transfer in ameliorating spinal cord injury
H Guo, L Chen, ZR Zou, S Cheng, Y Hu, L Mao… - European Journal of …, 2024 - Elsevier
Spinal cord injury (SCI) is a traumatic neuropathic condition that results in motor, sensory
and autonomic dysfunction. Mitochondrial dysfunction caused by primary trauma is one of …
and autonomic dysfunction. Mitochondrial dysfunction caused by primary trauma is one of …