Abstract Sirtuin 3 (SIRT3), an NAD+-dependent deacetylase, plays a key role in the
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …

Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …

Lung cancer is one of the leading causes of cancer-related deaths worldwide, and non-
small cell lung cancer (NSCLC) accounts for a large proportion of lung cancer cases, with …

The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of
target genes and diverse physiological processes. To precisely regulate the p53 network …

Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations
in cancer cells; however, most genomic regions sequenced in single cells are non …

Cholangiocarcinoma (CCA) is a malignant tumor of the digestive system, characterized by
its aggressive behavior and the absence of effective therapeutic biomarkers. Although …

Background: Renal cell carcinoma (RCC) is one of the most common malignant tumours of
the urinary system. However, the aetiology and pathogenesis of RCC remain unclear. The …

Background Drug resistance is a main factor affecting the chemotherapy efficacy of gastric
cancer (GC), in which meiosis plays an important role. Therefore, it is urgent to explore the …

The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …

Spinal cord injury (SCI) is a traumatic neuropathic condition that results in motor, sensory
and autonomic dysfunction. Mitochondrial dysfunction caused by primary trauma is one of …