Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be
causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute
respiratory disease and multiorgan failure. Finding human host factors that are essential for …

A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells
within a tumor, called tumor-initiating cells (TICs) or cancer stem cells (CSCs). Here we …

Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by
HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA …

It has been reported that the miR-106b∼ 25 cluster, a paralog of the miR-17∼ 92 cluster,
possesses oncogenic activities. However, the precise role of each microRNA (miRNA) in the …

Vascular endothelial growth factor (VEGF) is a dimeric glycoprotein that plays a crucial role
in microvascular complications of diabetes, including diabetic nephropathy. However, the …

Rationale: Viral myocarditis results from an adverse immune response to cardiotropic
viruses, which causes irreversible myocyte destruction and heart failure in previously …

High-risk HPV infection leads to aberrant expression of cellular oncogenic and tumor
suppressive miRNAs. A large number of these miRNA genes are downstream targets of the …

Angiogenesis, one of the hallmarks of cancer, is essential for both tumor growth and
metastasis. However, its molecular mechanisms in hepatocellular carcinoma (HCC) are …