Highlights•Parkinson's disease (PD) is a neurodegenerative disorder with complex
pathophysiological pathways.•The one-drug–single-target approach is inadequate in …

Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …

Diseases of the central nervous system are an alarming global problem showing an
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …

IRL790 ([2-(3-fluoro-5-methanesulfonylphenoxy) ethyl](propyl) amine, mesdopetam) is a
novel compound in development for the clinical management of motor and psychiatric …

In this study, we designed and synthesized heterobivalent ligands targeting heteromers
consisting of the metabotropic glutamate 5 receptor (mGluR5) and the dopamine D2 …

Homology model structures of the dopamine D2 receptor (D2R) were generated starting
from the active and inactive states of\upbeta β 2-adrenergic crystal structure templates. To …

Understanding the dopaminergic system is a priority in neurobiology and
neuropharmacology. Dopamine receptors are involved in the modulation of fundamental …

Imaging of dopamine D2/3 receptors (D2/3R) can shed light on the nature of several
neuropsychiatric disorders in which dysregulation of D2/3R signaling is involved. Agonist …

The aim of this study was to use a combined structure and pharmacophore modeling
approach to extract information regarding dopamine D1 receptor agonism and D1/D2 …

A series of mono-substituted 4-phenylpiperidines and-piperazines have been synthesized
and their effects on the dopaminergic system tested in vivo. The structure activity relationship …