The methodology of data-independent acquisition (DIA) within mass spectrometry (MS) was
developed into a method of choice for quantitative proteomics, to capture the depth and …

The investigation of neurodegenerative diseases advanced significantly with the advent of
cell-reprogramming technology, leading to the creation of new models of human illness …

The pathological huntingtin (HTT) trinucleotide repeat underlying Huntington disease (HD)
continues to expand throughout life. Repeat length correlates both with earlier age at onset …

In Huntington disease, cellular toxicity is particularly caused by toxic protein fragments
generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to …

X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the
Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type …

VPS13A disease and Huntington's disease (HD) are two basal ganglia disorders that may
be difficult to distinguish clinically because they have similar symptoms, neuropathological …

Huntington's disease is a hereditary incurable neurodegenerative disease caused by
expansion of the polyglutamine tract in exon 1 of the huntingtin gene. Huntingtin is a large …

Huntington's disease (HD) is a fatal neurodegenerative disorder that is caused by the
expansion of CAG repeats in the HTT gene, which results in a long polyglutamine (polyQ) …

In this chapter, we explored the alterations in receptor genes associated with Huntington's
disease (HD). The dysfunction and composition of receptor genes in HD are investigated …

Huntington's disease (HD) is a neurodegenerative disorder caused by an expansion of CAG
repeats in exon 1 of the HTT gene, ultimately resulting in the generation of a mutant HTT …