[HTML][HTML] Human organoids in basic research and clinical applications

XY Tang, S Wu, D Wang, C Chu, Y Hong… - Signal transduction and …, 2022 - nature.com
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

Engineered biomimetic hydrogels for organoids

Y Li, Q Saiding, Z Wang, W Cui - Progress in Materials Science, 2023 - Elsevier
Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or
adult stem cells cultured under laboratory conditions, emerge as a captivating model and …

[HTML][HTML] Newly developed 3D in vitro models to study tumor–immune interaction

P Mu, S Zhou, T Lv, F Xia, L Shen, J Wan… - Journal of Experimental …, 2023 - Springer
Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer
treatment and revitalized the field of tumor immunology research. 3D in vitro models are …

[HTML][HTML] Future regenerative medicine developments and their therapeutic applications

AE Altyar, A El-Sayed, A Abdeen, M Piscopo… - Biomedicine & …, 2023 - Elsevier
Although the currently available pharmacological assays can cure most pathological
disorders, they have limited therapeutic value in relieving certain disorders like myocardial …

[HTML][HTML] The use of stem cell-derived organoids in disease modeling: an update

J Azar, HF Bahmad, D Daher, MM Moubarak… - International Journal of …, 2021 - mdpi.com
Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

[HTML][HTML] Revolutionizing disease modeling: the emergence of organoids in cellular systems

R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Bioprinting of complex multicellular organs with advanced functionality—recent progress and challenges ahead

LE Bertassoni - Advanced Materials, 2022 - Wiley Online Library
Bioprinting has emerged as one of the most promising strategies for fabrication of functional
organs in the lab as an alternative to transplant organs. While progress in the field has …

[HTML][HTML] Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy

S Chaudhary, E Chakraborty - Beni-Suef University Journal of Basic and …, 2022 - Springer
Background Evolution in the in vitro cell culture from conventional 2D to 3D technique has
been a significant accomplishment. The 3D culture models have provided a close and better …

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis

AM de Waal, PS Hiemstra, THM Ottenhoff, SA Joosten… - Thorax, 2022 - thorax.bmj.com
The lung epithelium has long been overlooked as a key player in tuberculosis disease. In
addition to acting as a direct barrier to Mycobacterium tuberculosis (Mtb), epithelial cells …

[HTML][HTML] Harnessing the biology of canine intestinal organoids to heighten understanding of inflammatory bowel disease pathogenesis and accelerate drug discovery …

JJ Kopper, C Iennarella-Servantez, AE Jergens… - Frontiers in …, 2021 - frontiersin.org
In a recent issue of the Lancet, the prevalence of Inflammatory Bowel Disease (IBD) was
estimated at 7 million worldwide. Overall, the burden of IBD is rising globally, with direct and …